Description
The Menopause Plus Profile is an advanced salivary hormone test designed to evaluate hormonal balance during menopause, including sex hormones, sleep-related hormones, and adrenal function.
This panel provides a multi-dimensional view of hormonal health, going beyond basic hormone levels by incorporating melatonin patterns and optional cortisol awakening response (CAR).
👉 As shown in the sample report, this test includes estrogen, progesterone, testosterone, melatonin rhythm, and adrenal markers, offering a broader functional overview
🔬 What This Test Measures
1. Estrogens
- Estradiol (E2)
- Estrone (E1)
- Estriol (E3)
👉 Evaluates estrogen status during menopause
2. Progesterone
- Salivary progesterone
- Progesterone/Estradiol (P/E2) ratio
👉 Helps assess hormonal balance and relative dominance
3. Androgens
- Free testosterone
👉 Evaluates androgen levels affecting energy, mood, and metabolism
4. Adrenal Function (HPA Axis)
- Cortisol diurnal rhythm
- DHEA
- DHEA:Cortisol ratio
👉 Assesses stress response and adrenal balance
5. Sleep & Circadian Rhythm
- Melatonin (multiple time points)
👉 Provides insight into sleep quality and circadian rhythm regulation
6. Optional Add-On
- Cortisol Awakening Response (CAR)
👉 Measures early morning cortisol rise for advanced HPA axis evaluation
🧠 Clinical Insights
- Evaluates hormonal changes during menopause
- Assesses sleep disturbances linked to hormonal imbalance
- Identifies adrenal stress patterns
- Supports hormone therapy monitoring
👤 Who Should Consider This Test
- Menopausal or perimenopausal women
- Sleep disturbances (insomnia, poor sleep quality)
- Fatigue or stress-related symptoms
- Hormone replacement therapy monitoring
⚠️ Limitations
- ❌ Does not assess detailed hormone metabolism pathways
- ❌ No comprehensive estrogen detox analysis
- ❌ No thyroid evaluation
🔷 Key Clinical Insight
👉 This test answers:
“How are my hormones, sleep, and stress interacting during menopause?”
🔷 Final Summary
Menopause Plus is best suited for women experiencing hormonal imbalance along with sleep or stress-related symptoms, offering a more advanced assessment than basic menopause panels.





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