Cyrex Array 22 — Irritable Bowel / SIBO Screen

Description

Cyrex Array 22 — Irritable Bowel / SIBO Screen™

Many cases of IBS and SIBO are driven by post-infectious autoimmunity — molecular mimicry between bacterial toxins and gut nerve/muscle proteins. Array 22 identifies the autoimmune antibodies responsible for motility dysfunction and abnormal gut innervation, differentiating true autoimmune bowel disease from other causes of IBS-like symptoms.

Antigens Tested (IgG + IgA):

• Vinculin — cytoskeletal protein in the migrating motor complex (MMC); antibodies disrupt gut motility
• Cdtb (Cytolethal Distending Toxin B) — bacterial toxin from C. jejuni and other pathogens that triggers anti-vinculin autoimmunity
• CdtB/Vinculin complex antibodies

Why This Matters:

Dr Mark Pimentel’s research demonstrated that post-infectious IBS-D and SIBO with motility issues are driven by anti-CdtB and anti-vinculin antibodies. This is the only blood test that directly identifies this mechanism.

Clinical Applications:

• Differentiate post-infectious IBS from other IBS subtypes
• Unexplained SIBO with motility dysfunction
• Diarrhoea-predominant IBS (IBS-D)
• History of traveller’s diarrhoea or food poisoning

Sample Type:

Blood serum — single blood draw.

Array 22 – Irritable Bowel / SIBO Screen is a blood-based test that assesses immune activation triggered by bacterial overgrowth and toxin exposure in the gut.

Unlike breath tests that detect active bacterial fermentation, this test evaluates whether bacterial toxins have caused immune-mediated damage to intestinal tissues.

👉 As shown in the report, the test measures:

• Bacterial cytotoxins antibodies
• Cytoskeletal protein antibodies

These markers indicate whether microbial overgrowth has progressed to immune system involvement and tissue response.

🔬 What This Test Measures

1. Bacterial Cytotoxins

• IgG, IgA, IgM

👉 Indicates exposure to bacterial toxins in the gut

2. Cytoskeletal Proteins

• IgG, IgA, IgM

👉 Reflects damage to intestinal cells and structure

🧠 Clinical Insights

• Detects immune response to bacterial overgrowth (SIBO/IBS)
• Identifies toxin-induced gut damage
• Helps assess chronic IBS with immune involvement
• Supports evaluation of post-infectious gut dysfunction

⚠️ Important Distinction

👉 This is NOT a diagnostic test for SIBO
👉 It detects immune consequences of SIBO

🔷 Array 22 vs Genova SIBO Breath Test

🔥 When to Choose What

👉 Choose Genova SIBO Test
✔ If you want to confirm: “Do I have SIBO?”

👉 Choose Cyrex Array 22
✔ If you want to know: “Has SIBO triggered immune damage?”