Description

DUTCH Plus®

Description

The DUTCH Plus® is an advanced hormone test that combines comprehensive hormone analysis with the Cortisol Awakening Response (CAR), providing a complete evaluation of hormonal balance and the body’s stress response system.

It includes everything in the DUTCH Complete™ along with CAR testing, offering deeper insight into how the body produces, metabolizes, and responds to stress throughout the day.

What This Test Measures

Sex Hormones & Metabolism

• Estrogen (E1, E2, E3)
• Progesterone metabolites
• Androgens (testosterone, DHEA)
• Estrogen metabolism pathways (2-OH, 4-OH, 16-OH)

Adrenal Function

• Free cortisol (daily rhythm)
• Cortisol metabolites (total production)
• DHEA-S

Cortisol Awakening Response (CAR)

• Cortisol at waking, +30 min, +60 min
• Measures early-morning stress response and HPA axis function

Organic Acid Markers (OATs)

• Oxidative stress (8-OHdG)
• Melatonin (6-OHMS)
• Vitamin B12 (methylmalonate)
• Vitamin B6 markers
• Neurotransmitters (dopamine, norepinephrine)

👉 Includes 42 hormones, metabolites, and functional markers in one panel

What You Learn

• Complete hormone balance and metabolism
• Adrenal function and cortisol rhythm
• Morning stress response and resilience (CAR)
• Sleep quality via melatonin
• Nutritional status and oxidative stress
• Neurotransmitter balance and brain chemistry

Who Should Consider This Test

• Chronic fatigue or burnout (especially morning fatigue)
• Anxiety, depression, or high stress
• Sleep disturbances or insomnia
• Hormonal imbalance with stress component
• Suspected adrenal or HPA axis dysfunction

Sample Collection

• 4–5 dried urine samples over 24 hours
• 5–6 saliva samples for CAR measurement

Why Choose DUTCH Over Other Tests?

Blood Testing

• Single-point measurement

Saliva Testing

• Limited metabolic insight

DUTCH Testing

• Measures hormone levels, metabolism, and stress response together

👉 Provides a more complete and clinically actionable picture of hormonal health