Description
DUTCH Sex Hormone Metabolites — Estrogen & Androgen Pathways
This focused panel maps estrogen and androgen metabolism pathways in detail, identifying how your body processes and eliminates sex hormones. It is ideal for assessing breast cancer risk, estrogen dominance, PCOS, and androgen excess without the full adrenal panel.
Key Biomarkers Measured:
- Estrogen metabolites: Estradiol (E2), Estrone (E1), Estriol (E3), 2-OH-E1, 4-OH-E1, 16-OH-E1, 2-methoxy-E1
- Estrogen metabolism ratio: 2/16-OH ratio (protective vs. proliferative pathway)
- Androgen metabolites: Testosterone, DHEA-S, Androsterone, Etiocholanolone, 5α-DHT
- Progesterone metabolites: Pregnanediol, Allopregnanolone
Who Should Order This Test:
- Women with estrogen dominance symptoms (heavy periods, fibroids, breast tenderness)
- Breast or hormone-sensitive cancer risk assessment
- PCOS and androgen excess evaluation
- Monitoring hormone therapy or detoxification protocols
Sample Type:
Dried urine — single collection.





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