Description
Why is it necessary to test Iodine levels in the body? What functions does Iodine perform in our body? What problems does one face if there is Iodine insufficiency?
Specific tissues in the body require adequate iodine and the reduced form of the element, iodide, for normal metabolism and optimal health. Adequate iodide uptake and organification of iodine by the thyroid gland is required for the production, storage, and release of thyroid hormones. Triiodothyronine (T3) regulates metabolism in several tissues by affecting energy production and neuronal and sexual development. Iodine insufficiency is associated with "sub-clinical" thyroid deficiency, weight gain, loss of energy, goiter and impaired mental function. Iodine is also concentrated in breast tissue where it elicits anti-proliferative effects and protection against fibrocystic breast disease and cancer. Iodine and organic iodine compounds are also concentrated and secreted by the gastric mucosa, salivary glands, and the cervix.
Why is it necessary to test for Bromide and Flouride along with Iodine as well?
Iodine status and metabolism are affected not only by iodine intake, which has decreased significantly but also by intake and retention of goitrogenic halides bromide and fluoride. Excessive intake of the antagonistic halides can accumulate in tissues, displace iodine and compromise the production of thyroid hormones and the integrity of the thyroid and mammary glands.
What is the source of Bromide and Fluoride in our body?
Antagonistic bromide is abundant in commercially produced baked goods, soft drinks, pesticides, brominated chemicals and some medications. Primary sources of fluoride include fluoridated water, beverages, toothpaste, mouthwashes and some medications.
How is this test performed? What is required for carrying out this test?
The Urine Halides test provides a comprehensive assessment of iodine sufficiency and retention of antagonistic halides in a single test. The test requires a spot urine specimen, preferably first-morning void (FMV), for determination of baseline halide levels. An oral loading dose of iodine/iodide is ingested and all urine is co
llected for the subsequent 24 hours. Iodine and displaced bromide and fluoride are measured in the urine and the results for each element are reported as µg/gm creatinine and µg/24 hours. Iodine status is assessed by evaluation of the percentage of the ingested dose that is excreted. Low iodine excretion is suggestive of greater bodily retention and need.
What methodology is used for measurements of these halides?
The specific halides are analyzed in urine using the most accurate methodology available for each element. Iodine and bromine are measured by ICP-MS as is used by the CDC. Fluoride is measured by ion selective electrode (ISE).
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